The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus

Hepatitis C virus (HCV) NS3-4A is required for viral replication and assembly. We establish that virus assembly is sensitive to mutations in the linker region between the helicase and protease domains of NS3-4A. However, we find that the protease cleavage, RNA binding, and unwinding rates of NS3 are...

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Detalhes bibliográficos
Main Authors: Kohlway, Andrew, Pirakitikulr, Nathan, Ding, Steve C., Yang, Feng, Luo, Dahai, Lindenbach, Brett D., Pyle, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178846/
https://ncbi.nlm.nih.gov/pubmed/24965468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00745-14
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