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The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
Hepatitis C virus (HCV) NS3-4A is required for viral replication and assembly. We establish that virus assembly is sensitive to mutations in the linker region between the helicase and protease domains of NS3-4A. However, we find that the protease cleavage, RNA binding, and unwinding rates of NS3 are...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Microbiology
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4178846/ https://ncbi.nlm.nih.gov/pubmed/24965468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00745-14 |
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