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DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B

Genome-wide DNA methylation patterns are frequently deregulated in cancer. There is considerable interest in targeting the methylation machinery in tumor cells using nucleoside analogs of cytosine, such as 5-aza-2′-deoxycytidine (5-azadC). 5-azadC exerts its antitumor effects by reactivation of aber...

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書誌詳細
主要な著者: Palii, Stela S., Van Emburgh, Beth O., Sankpal, Umesh T., Brown, Kevin D., Robertson, Keith D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223421/
https://ncbi.nlm.nih.gov/pubmed/17991895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01799-07
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