Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.

Inhibitors of ornithine decarboxylase (ODC), such as alpha-difluoromethylornithine (DFMO), may influence the cytotoxicity of anti-tumour agents that interact with DNA. Intracellular levels of putrescine and spermidine were markedly reduced by ODC inhibitors while the level of spermine, which is the...

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Bibliographic Details
Main Authors: Desiderio, M. A., Bergamaschi, D., Mascellani, E., De Feudis, P., Erba, E., D'Incalci, M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222756/
https://ncbi.nlm.nih.gov/pubmed/9083339
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