Lipophilic Lysine-Spermine Conjugates are Potent Polyamine Transport Inhibitors for use in Combination with a Polyamine Biosynthesis Inhibitor

Cancer cells can overcome the ability of polyamine biosynthesis inhibitors from completely depleting their internal polyamines by the importation polyamines from external sources. We have developed a group of lipophilic polyamine analogs that potently inhibit the cellular polyamine uptake system and...

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Detalhes bibliográficos
Main Authors: Burns, Mark R., Graminski, Gerard F., Weeks, Reitha S., Chen, Yan, O’Brien, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714422/
https://ncbi.nlm.nih.gov/pubmed/19281226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801580w
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