Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase

Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned o...

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Bibliografski detalji
Izdano u:J Enzyme Inhib Med Chem
Glavni autori: Di Paolo, Maria Luisa, Cervelli, Manuela, Mariottini, Paolo, Leonetti, Alessia, Polticelli, Fabio, Rosini, Michela, Milelli, Andrea, Basagni, Filippo, Venerando, Rina, Agostinelli, Enzo, Minarini, Anna
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407594/
https://ncbi.nlm.nih.gov/pubmed/30829081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1584620
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