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The Evolution of Two Mutations During Clonal Expansion
Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Genetics Society of America
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2219486/ https://ncbi.nlm.nih.gov/pubmed/18073428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.078915 |
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