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On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K(+) Channel, hKv1.5

4-Aminopyridine (4-AP) binds to potassium channels at a site or sites in the inner mouth of the pore and is thought to prevent channel opening. The return of hKv1.5 off-gating charge upon repolarization is accelerated by 4-AP and it has been suggested that 4-AP blocks slow conformational rearrangeme...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Fred S.P., Fedida, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217124/
https://ncbi.nlm.nih.gov/pubmed/9524137
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