Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell–mediated lysis of myeloma

Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell–mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple myeloma (MM). We hypothesized that treatment of MM wit...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Shi, Jumei, Tricot, Guido J., Garg, Tarun K., Malaviarachchi, Priyangi A., Szmania, Susann M., Kellum, Rachel E., Storrie, Brian, Mulder, Arend, Shaughnessy, John D., Barlogie, Bart, van Rhee, Frits
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2008
Aiheet:
Immunobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214736/
https://ncbi.nlm.nih.gov/pubmed/17947507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-078535
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