Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell–mediated lysis of myeloma

Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell–mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple myeloma (MM). We hypothesized that treatment of MM wit...

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Hlavní autoři: Shi, Jumei, Tricot, Guido J., Garg, Tarun K., Malaviarachchi, Priyangi A., Szmania, Susann M., Kellum, Rachel E., Storrie, Brian, Mulder, Arend, Shaughnessy, John D., Barlogie, Bart, van Rhee, Frits
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214736/
https://ncbi.nlm.nih.gov/pubmed/17947507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-078535
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