Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell–mediated lysis of myeloma

Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell–mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple myeloma (MM). We hypothesized that treatment of MM wit...

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Détails bibliographiques
Auteurs principaux: Shi, Jumei, Tricot, Guido J., Garg, Tarun K., Malaviarachchi, Priyangi A., Szmania, Susann M., Kellum, Rachel E., Storrie, Brian, Mulder, Arend, Shaughnessy, John D., Barlogie, Bart, van Rhee, Frits
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2008
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214736/
https://ncbi.nlm.nih.gov/pubmed/17947507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-078535
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