Epigenetic modulation of MAGE-A3 antigen expression in multiple myeloma following treatment with the demethylation agent 5-azacitidine and the histone deacetlyase inhibitor MGCD0103

BACKGROUND AIMS: Immunotherapy targeting MAGE-A3 in multiple myeloma (MM) could eradicate highly aggressive and proliferative clonal cell populations responsible for relapse. However, expression of many cancer-testis antigens, including MAGE-A3, can be heterogeneous, leading to the potential for tum...

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Main Authors: Moreno-Bost, Amberly, Szmania, Susann, Stone, Katie, Garg, Tarun, Hoerring, Antje, Szymonifka, Jackie, Shaughnessy, John, Barlogie, Bart, Prentice, H. Grant, Van Rhee, Frits
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633222/
https://ncbi.nlm.nih.gov/pubmed/21171821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14653249.2010.529893
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