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Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT(3) and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

Cys-loop receptor neurotransmitter-gated ion channels are pentameric assemblies of subunits that contain three domains: extracellular, transmembrane, and intracellular. The extracellular domain forms the agonist binding site. The transmembrane domain forms the ion channel. The cytoplasmic domain is...

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Autors principals: Jansen, Michaela, Bali, Moez, Akabas, Myles H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213565/
https://ncbi.nlm.nih.gov/pubmed/18227272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709896
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