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GABA-Induced Intersubunit Conformational Movement in the GABA(A) Receptor α1M1-β2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site
The molecular basis of general anesthetic interactions with GABA(A) receptors is uncertain. An accurate homology model would facilitate studies of anesthetic action. Construction of a GABA(A) model based on the 4 Å resolution acetylcholine receptor structure is complicated by alignment uncertainty b...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for Neuroscience
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677711/ https://ncbi.nlm.nih.gov/pubmed/19279245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6090-08.2009 |
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