Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of cytotoxic T lymphocyte (CTL)-mediated selection pressure and immune escape. The associations most frequently...

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Autors principals: Leslie, Alasdair, Kavanagh, Daniel, Honeyborne, Isobella, Pfafferott, Katja, Edwards, Charles, Pillay, Tilly, Hilton, Louise, Thobakgale, Christina, Ramduth, Danni, Draenert, Rika, Le Gall, Sylvie, Luzzi, Graz, Edwards, Anne, Brander, Christian, Sewell, Andrew K., Moore, Sarah, Mullins, James, Moore, Corey, Mallal, Simon, Bhardwaj, Nina, Yusim, Karina, Phillips, Rodney, Klenerman, Paul, Korber, Bette, Kiepiela, Photini, Walker, Bruce, Goulder, Philip
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213090/
https://ncbi.nlm.nih.gov/pubmed/15781581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041455
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