Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen processing have not been defined in natural human infections. In human histocompatibility leukocyte antigen (HLA)-B57(+) HIV-infected persons, immune...

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Main Authors: Draenert, Rika, Le Gall, Sylvie, Pfafferott, Katja J., Leslie, Alasdair J., Chetty, Polan, Brander, Christian, Holmes, Edward C., Chang, Shih-Chung, Feeney, Margaret E., Addo, Marylyn M., Ruiz, Lidia, Ramduth, Danni, Jeena, Prakash, Altfeld, Marcus, Thomas, Stephanie, Tang, Yanhua, Verrill, Cori L., Dixon, Catherine, Prado, Julia G., Kiepiela, Photini, Martinez-Picado, Javier, Walker, Bruce D., Goulder, Philip J.R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211885/
https://ncbi.nlm.nih.gov/pubmed/15067030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031982
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