Avidity for antigen shapes clonal dominance in CD8(+) T cell populations specific for persistent DNA viruses

The forces that govern clonal selection during the genesis and maintenance of specific T cell responses are complex, but amenable to decryption by interrogation of constituent clonotypes within the antigen-experienced T cell pools. Here, we used point-mutated peptide–major histocompatibility complex...

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Detalhes bibliográficos
Main Authors: Price, David A., Brenchley, Jason M., Ruff, Laura E., Betts, Michael R., Hill, Brenna J., Roederer, Mario, Koup, Richard A., Migueles, Steven A., Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K., Connors, Mark, Douek, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212993/
https://ncbi.nlm.nih.gov/pubmed/16287711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051357
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