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Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFN β) gene. Here,...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2005
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212973/ https://ncbi.nlm.nih.gov/pubmed/16301743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051654 |
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