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Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFN β) gene. Here,...

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Detalhes bibliográficos
Main Authors: Okabe, Yasutaka, Kawane, Kohki, Akira, Shizuo, Taniguchi, Tadatsugu, Nagata, Shigekazu
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212973/
https://ncbi.nlm.nih.gov/pubmed/16301743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051654
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