Llwytho...

Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFN β) gene. Here,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Okabe, Yasutaka, Kawane, Kohki, Akira, Shizuo, Taniguchi, Tadatsugu, Nagata, Shigekazu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212973/
https://ncbi.nlm.nih.gov/pubmed/16301743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051654
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