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Modifier loci condition autoimmunity provoked by Aire deficiency
Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice lead to autoimmune manifestations that segregate as a monogenic trait, but with wide variation in the spectrum of organs targeted. To investig...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212943/ https://ncbi.nlm.nih.gov/pubmed/16172259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050693 |
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