Notch1 modulates timing of G(1)-S progression by inducing SKP2 transcription and p27(Kip1) degradation

Cyclin-dependent kinase inhibitors (CKIs) and Notch receptor activation have been shown to influence adult stem cells and progenitors by altering stem cell self-renewal and proliferation. Yet, no interaction between these molecular pathways has been defined. Here we show that ligand-independent and...

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Huvudupphovsmän: Sarmento, Leonor M., Huang, Hui, Limon, Ana, Gordon, William, Fernandes, Jacquenilson, Tavares, Maria J., Miele, Lucio, Cardoso, Angelo A., Classon, Marie, Carlesso, Nadia
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2005
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212905/
https://ncbi.nlm.nih.gov/pubmed/15998794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050559
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