Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27(Kip1)

Müller glia (MG), the sole glial cells generated by retinal progenitors, have emerged as a viable cellular target for therapeutic regeneration in degenerative blinding diseases, as they possess dormant stem cell properties. However, the mammalian MG does not display the neurogenic potential of their...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Del Debbio, Carolina Beltrame, Mir, Qulsum, Parameswaran, Sowmya, Mathews, Saumi, Xia, Xiaohuan, Zheng, Li, Neville, Andrew J., Ahmad, Iqbal
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806989/
https://ncbi.nlm.nih.gov/pubmed/27011052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152025
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