Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27(Kip1)

Müller glia (MG), the sole glial cells generated by retinal progenitors, have emerged as a viable cellular target for therapeutic regeneration in degenerative blinding diseases, as they possess dormant stem cell properties. However, the mammalian MG does not display the neurogenic potential of their...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Del Debbio, Carolina Beltrame, Mir, Qulsum, Parameswaran, Sowmya, Mathews, Saumi, Xia, Xiaohuan, Zheng, Li, Neville, Andrew J., Ahmad, Iqbal
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806989/
https://ncbi.nlm.nih.gov/pubmed/27011052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152025
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