Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT) can persistently suppress inflammatory disease activity in a subset of patients with severe multiple sclerosis (MS), but the mechanism has remained unclear. To understand whether the beneficial effects on t...

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Main Authors: Muraro, Paolo A., Douek, Daniel C., Packer, Amy, Chung, Katherine, Guenaga, Francisco J., Cassiani-Ingoni, Riccardo, Campbell, Catherine, Memon, Sarfraz, Nagle, James W., Hakim, Frances T., Gress, Ronald E., McFarland, Henry F., Burt, Richard K., Martin, Roland
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212822/
https://ncbi.nlm.nih.gov/pubmed/15738052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041679
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