IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In contrast, IL-23 does not promote the development...

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Bibliographic Details
Main Authors: Langrish, Claire L., Chen, Yi, Blumenschein, Wendy M., Mattson, Jeanine, Basham, Beth, Sedgwick, Jonathan D., McClanahan, Terrill, Kastelein, Robert A., Cua, Daniel J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212798/
https://ncbi.nlm.nih.gov/pubmed/15657292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041257
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