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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhanced proliferation, inhibition of apoptosis, and oncogenesis. Human SK (hSK) 1 possesses high instrinsic catalyt...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212769/ https://ncbi.nlm.nih.gov/pubmed/15623571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040559 |
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