Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhanced proliferation, inhibition of apoptosis, and oncogenesis. Human SK (hSK) 1 possesses high instrinsic catalyt...

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Main Authors: Pitson, Stuart M., Xia, Pu, Leclercq, Tamara M., Moretti, Paul A.B., Zebol, Julia R., Lynn, Helen E., Wattenberg, Binks W., Vadas, Mathew A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212769/
https://ncbi.nlm.nih.gov/pubmed/15623571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040559
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