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An oncogenic role for sphingosine kinase 2

While both human sphingosine kinases (SK1 and SK2) catalyze the generation of the pleiotropic signaling lipid sphingosine 1-phosphate, these enzymes appear to be functionally distinct. SK1 has well described roles in promoting cell survival, proliferation and neoplastic transformation. The roles of...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Neubauer, Heidi A., Pham, Duyen H., Zebol, Julia R., Moretti, Paul A.B., Peterson, Amanda L., Leclercq, Tamara M., Chan, Huasheng, Powell, Jason A., Pitman, Melissa R., Samuel, Michael S., Bonder, Claudine S., Creek, Darren J., Gliddon, Briony L., Pitson, Stuart M.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323123/
https://ncbi.nlm.nih.gov/pubmed/27588496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11714
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