A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer. Sphingosine 1-phosphate is a signaling molecule with anti-apoptotic, pro-proliferative and pro-angiogenic effects, while conversely, ceramide and...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Pitman, Melissa R., Powell, Jason A., Coolen, Carl, Moretti, Paul A.B., Zebol, Julia R., Pham, Duyen H., Finnie, John W., Don, Anthony S., Ebert, Lisa M., Bonder, Claudine S., Gliddon, Briony L., Pitson, Stuart M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466670/
https://ncbi.nlm.nih.gov/pubmed/25788259
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