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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition of COX-1. Here we report data from two related assay systems, the human whole blood assay and a modified...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Warner, Timothy D., Giuliano, Francesco, Vojnovic, Ivana, Bukasa, Antoaneta, Mitchell, Jane A., Vane, John R.
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 1999
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC22126/
https://ncbi.nlm.nih.gov/pubmed/10377455
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