Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition of COX-1. Here we report data from two related assay systems, the human whole blood assay and a modified...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Warner, Timothy D., Giuliano, Francesco, Vojnovic, Ivana, Bukasa, Antoaneta, Mitchell, Jane A., Vane, John R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22126/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10377455/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.13.7563
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