Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

Amyloid precursor proteins (APPs) are expressed in multiple organs and cell types in diverse species. Their conservation across species and high abundance in brain and the association of various APP missense mutations with autosomal dominant forms of familial Alzheimer’s disease (FAD) suggest import...

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Hlavní autoři: Xu, Xiao, Yang, Daseng, Wyss-Coray, Tony, Yan, Jim, Gan, Li, Sun, Yi, Mucke, Lennart
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22123/
https://ncbi.nlm.nih.gov/pubmed/10377452
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