Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein

Forced overexpression of wild-type Alzheimer amyloid precursor protein (APP) causes postmitotic neurons to degenerate. Caspase-3 (CPP32) is a principal cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. Here, we investigated whether...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Uetsuki, Taichi, Takemoto, Kiwamu, Nishimura, Isao, Okamoto, Mariko, Niinobe, Michio, Momoi, Takashi, Miura, Masayuki, Yoshikawa, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 1999
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782871/
https://ncbi.nlm.nih.gov/pubmed/10436052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-16-06955.1999
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