Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer

In an attempt to elucidate the pathological implications of intracellular accumulation of the amyloid precursor protein (APP) in postmitotic neurons in vivo, we transferred APP695 cDNA into rat hippocampal neurons by using a replication-defective adenovirus vector. We first improved the efficiency o...

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Publicat a:J Neurosci
Autors principals: Nishimura, Isao, Uetsuki, Taichi, Dani, Sergio U., Ohsawa, Yoshiyuki, Saito, Izumu, Okamura, Hitoshi, Uchiyama, Yasuo, Yoshikawa, Kazuaki
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1998
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793123/
https://ncbi.nlm.nih.gov/pubmed/9502800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-07-02387.1998
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