Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer

In an attempt to elucidate the pathological implications of intracellular accumulation of the amyloid precursor protein (APP) in postmitotic neurons in vivo, we transferred APP695 cDNA into rat hippocampal neurons by using a replication-defective adenovirus vector. We first improved the efficiency o...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nishimura, Isao, Uetsuki, Taichi, Dani, Sergio U., Ohsawa, Yoshiyuki, Saito, Izumu, Okamura, Hitoshi, Uchiyama, Yasuo, Yoshikawa, Kazuaki
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793123/
https://ncbi.nlm.nih.gov/pubmed/9502800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-07-02387.1998
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