Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer

In an attempt to elucidate the pathological implications of intracellular accumulation of the amyloid precursor protein (APP) in postmitotic neurons in vivo, we transferred APP695 cDNA into rat hippocampal neurons by using a replication-defective adenovirus vector. We first improved the efficiency o...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Nishimura, Isao, Uetsuki, Taichi, Dani, Sergio U., Ohsawa, Yoshiyuki, Saito, Izumu, Okamura, Hitoshi, Uchiyama, Yasuo, Yoshikawa, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 1998
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793123/
https://ncbi.nlm.nih.gov/pubmed/9502800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-07-02387.1998
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