Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein

Forced overexpression of wild-type Alzheimer amyloid precursor protein (APP) causes postmitotic neurons to degenerate. Caspase-3 (CPP32) is a principal cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. Here, we investigated whether...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Uetsuki, Taichi, Takemoto, Kiwamu, Nishimura, Isao, Okamoto, Mariko, Niinobe, Michio, Momoi, Takashi, Miura, Masayuki, Yoshikawa, Kazuaki
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1999
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782871/
https://ncbi.nlm.nih.gov/pubmed/10436052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-16-06955.1999
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items