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Role of Dimerization of the Membrane-associated Growth Factor Kit Ligand in Juxtacrine Signaling: The Sl (17H) Mutation Affects Dimerization and Stability—Phenotypes in Hematopoiesis

The Kit ligand (KL)/Kit receptor pair functions in hematopoiesis, gametogenesis, and melanogenesis. KL is encoded at the murine steel (Sl) locus and encodes a membrane growth factor which may be proteolytically processed to produce soluble KL. The membrane-associated form of KL is critical in mediat...

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Библиографические подробности
Главные авторы: Tajima, Youichi, Huang, Eric J., Vosseller, Keith, Ono, Masao, Moore, Malcolm A.S., Besmer, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 1998
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212272/
https://ncbi.nlm.nih.gov/pubmed/9565637
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