CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

Prediabetes and diabetes in nonobese diabetic (NOD) mice have been targeted by a variety of immunotherapies, including the use of a soluble form of cytotoxic T lymphocyte antigen 4 (CTLA-4) and interferon (IFN)-γ. The cytokine, however, fails to activate tolerogenic properties in dendritic cells (DC...

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Autors principals: Fallarino, Francesca, Bianchi, Roberta, Orabona, Ciriana, Vacca, Carmine, Belladonna, Maria L., Fioretti, Maria C., Serreze, David V., Grohmann, Ursula, Puccetti, Paolo
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211844/
https://ncbi.nlm.nih.gov/pubmed/15492127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040942
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