Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

Indoleamine 2,3-dioxygenase (IDO1), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions. We have recently demonstrated that IDO1 does not merely degrade tryptophan and produce immunoregulatory kynurenines, but it also acts as a...

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Detalhes bibliográficos
Main Authors: Pallotta, Maria Teresa, Orabona, Ciriana, Bianchi, Roberta, Vacca, Carmine, Fallarino, Francesca, Belladonna, Maria Laura, Volpi, Claudia, Mondanelli, Giada, Gargaro, Marco, Allegrucci, Massimo, Talesa, Vincenzo Nicola, Puccetti, Paolo, Grohmann, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193887/
https://ncbi.nlm.nih.gov/pubmed/25215657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12360
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