Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

Indoleamine 2,3-dioxygenase (IDO1), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions. We have recently demonstrated that IDO1 does not merely degrade tryptophan and produce immunoregulatory kynurenines, but it also acts as a...

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Autors principals: Pallotta, Maria Teresa, Orabona, Ciriana, Bianchi, Roberta, Vacca, Carmine, Fallarino, Francesca, Belladonna, Maria Laura, Volpi, Claudia, Mondanelli, Giada, Gargaro, Marco, Allegrucci, Massimo, Talesa, Vincenzo Nicola, Puccetti, Paolo, Grohmann, Ursula
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193887/
https://ncbi.nlm.nih.gov/pubmed/25215657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12360
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