SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

Despite their common ability to activate intracellular signaling through CD80/CD86 molecules, cytotoxic T lymphocyte antigen 4 (CTLA-4)-Ig and CD28-Ig bias the downstream response in opposite directions, the latter promoting immunity, and CTLA-4-Ig tolerance, in dendritic cells (DCs) with opposite b...

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Detalhes bibliográficos
Main Authors: Orabona, Ciriana, Pallotta, Maria T., Volpi, Claudia, Fallarino, Francesca, Vacca, Carmine, Bianchi, Roberta, Belladonna, Maria L., Fioretti, Maria C., Grohmann, Ursula, Puccetti, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634889/
https://ncbi.nlm.nih.gov/pubmed/19088199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810278105
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