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Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death
Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T lineage and show here that loss of survivin blocks the transition from CD4(−) CD8(−) double negative (DN)...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211792/ https://ncbi.nlm.nih.gov/pubmed/14757745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032092 |
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