Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death

Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T lineage and show here that loss of survivin blocks the transition from CD4(−) CD8(−) double negative (DN)...

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Main Authors: Okada, Hitoshi, Bakal, Chris, Shahinian, Arda, Elia, Andrew, Wakeham, Andrew, Suh, Woong-Kyung, Duncan, Gordon S., Ciofani, Maria, Rottapel, Robert, Zúñiga-Pflücker, Juan Carlos, Mak, Tak W.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211792/
https://ncbi.nlm.nih.gov/pubmed/14757745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032092
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