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p53 regulates the cardiac transcriptome

The tumor suppressor Trp53 (p53) inhibits cell growth after acute stress by regulating gene transcription. The mammalian genome contains hundreds of p53-binding sites. However, whether p53 participates in the regulation of cardiac tissue homeostasis under normal conditions is not known. To examine t...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Mak, Tak W., Hauck, Ludger, Grothe, Daniela, Billia, Filio
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338492/
https://ncbi.nlm.nih.gov/pubmed/28193895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621436114
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