p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs

Defining the roadblocks responsible for cell cycle arrest in adult cardiomyocytes lies at the core of developing cardiac regenerative therapies. p53 and Mdm2 are crucial mediators of cell cycle arrest in proliferative cell types, however, little is known about their function in regulating homeostasi...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Stanley-Hasnain, Shanna, Hauck, Ludger, Grothe, Daniela, Aschar-Sobbi, Roozbeh, Beca, Sanja, Butany, Jagdish, Backx, Peter H., Mak, Tak W., Billia, Filio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587026/
https://ncbi.nlm.nih.gov/pubmed/28745540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1346758
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