p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs

Defining the roadblocks responsible for cell cycle arrest in adult cardiomyocytes lies at the core of developing cardiac regenerative therapies. p53 and Mdm2 are crucial mediators of cell cycle arrest in proliferative cell types, however, little is known about their function in regulating homeostasi...

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I publikationen:Cell Cycle
Huvudupphovsmän: Stanley-Hasnain, Shanna, Hauck, Ludger, Grothe, Daniela, Aschar-Sobbi, Roozbeh, Beca, Sanja, Butany, Jagdish, Backx, Peter H., Mak, Tak W., Billia, Filio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2017
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Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587026/
https://ncbi.nlm.nih.gov/pubmed/28745540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1346758
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