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p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1
FKHRL1 (FOXO3a) and p53 are two potent stress-response regulators. Here we show that these two transcription factors exhibit “crosstalk” in vivo. In response to DNA damage, p53 activation led to FKHRL1 phosphorylation and subcellular localization change, which resulted in inhibition of FKHRL1 transc...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521120/ https://ncbi.nlm.nih.gov/pubmed/15383658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406286101 |
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