p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

FKHRL1 (FOXO3a) and p53 are two potent stress-response regulators. Here we show that these two transcription factors exhibit “crosstalk” in vivo. In response to DNA damage, p53 activation led to FKHRL1 phosphorylation and subcellular localization change, which resulted in inhibition of FKHRL1 transc...

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Bibliographic Details
Main Authors: You, Han, Jang, YingJu, You-Ten, Annick Itie, Okada, Hitoshi, Liepa, Jennifer, Wakeham, Andrew, Zaugg, Kathrin, Mak, Tak W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521120/
https://ncbi.nlm.nih.gov/pubmed/15383658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406286101
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