p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

FKHRL1 (FOXO3a) and p53 are two potent stress-response regulators. Here we show that these two transcription factors exhibit “crosstalk” in vivo. In response to DNA damage, p53 activation led to FKHRL1 phosphorylation and subcellular localization change, which resulted in inhibition of FKHRL1 transc...

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Detaylı Bibliyografya
Asıl Yazarlar: You, Han, Jang, YingJu, You-Ten, Annick Itie, Okada, Hitoshi, Liepa, Jennifer, Wakeham, Andrew, Zaugg, Kathrin, Mak, Tak W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC521120/
https://ncbi.nlm.nih.gov/pubmed/15383658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406286101
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