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Ubiquitin-dependent Degradation of p73 Is Inhibited by PML

p73 has been identified recently as a structural and functional homologue of the tumor suppressor p53. Here, we report that p73 stability is directly regulated by the ubiquitin–proteasome pathway. Furthermore, we show that the promyelocytic leukemia (PML) protein modulates p73 half-life by inhibitin...

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Bibliografski detalji
Glavni autori: Bernassola, Francesca, Salomoni, Paolo, Oberst, Andrew, Di Como, Charles J., Pagano, Michele, Melino, Gerry, Pandolfi, Pier Paolo
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211783/
https://ncbi.nlm.nih.gov/pubmed/15184504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031943
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