A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

By transfer of T cell receptor (TCR) genes, antigen specificity of T cells can be redirected to target any antigen. Adoptive transfer of TCR-redirected T cells into patients has shown promising results. However, this immunotherapy bears the risk of autoreactive side effects if the TCR recognizes ant...

Full description

Saved in:
Bibliographic Details
Main Authors: Kieback, Elisa, Charo, Jehad, Sommermeyer, Daniel, Blankenstein, Thomas, Uckert, Wolfgang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206586/
https://ncbi.nlm.nih.gov/pubmed/18182487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710198105
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items