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A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
By transfer of T cell receptor (TCR) genes, antigen specificity of T cells can be redirected to target any antigen. Adoptive transfer of TCR-redirected T cells into patients has shown promising results. However, this immunotherapy bears the risk of autoreactive side effects if the TCR recognizes ant...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206586/ https://ncbi.nlm.nih.gov/pubmed/18182487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710198105 |
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