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Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase

RNA helicases couple the energy from ATP hydrolysis with structural changes of their RNA substrates. DEAD box helicases form the largest class of RNA helicases and share a helicase core comprising two RecA-like domains. An opening and closing of the interdomain cleft during RNA unwinding has been po...

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Main Authors: Theissen, Bettina, Karow, Anne R., Köhler, Jürgen, Gubaev, Airat, Klostermeier, Dagmar
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206573/
https://ncbi.nlm.nih.gov/pubmed/18184816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705488105
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