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Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
Children with Down syndrome (DS) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific effects of trisomy 21 on hematopoiesis remain poorly defined. To study this question, we analyzed blood cell development in the Ts65Dn mou...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200841/ https://ncbi.nlm.nih.gov/pubmed/17901249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-085670 |
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