Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

Children with Down syndrome (DS) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific effects of trisomy 21 on hematopoiesis remain poorly defined. To study this question, we analyzed blood cell development in the Ts65Dn mou...

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Autori principali: Kirsammer, Gina, Jilani, Sarah, Liu, Hui, Davis, Elizabeth, Gurbuxani, Sandeep, Le Beau, Michelle M., Crispino, John D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200841/
https://ncbi.nlm.nih.gov/pubmed/17901249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-085670
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