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Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of...

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Detalhes bibliográficos
Main Authors: Best, Tyler K., Cramer, Nathan P., Chakrabarti, Lina, Haydar, Tarik F., Galdzicki, Zygmunt
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123861/
https://ncbi.nlm.nih.gov/pubmed/22178330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.11.033
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