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Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of...

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Bibliografiske detaljer
Main Authors: Best, Tyler K., Cramer, Nathan P., Chakrabarti, Lina, Haydar, Tarik F., Galdzicki, Zygmunt
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123861/
https://ncbi.nlm.nih.gov/pubmed/22178330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.11.033
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